| 1 | October 01, 2020 CET: 20:00 | Olympiacos Piraeus OLY | 67-68 | Zalgiris Kaunas ZAL |
| 2 | October 10, 2020 CET: 19:00 | Khimki Moscow Region KHI | 70-84 | Zalgiris Kaunas ZAL |
| 3 | October 13, 2020 CET: 19:00 | Crvena Zvezda mts Belgrade CZV | 69-75 | Zalgiris Kaunas ZAL |
| 4 | October 15, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 89-73 | Anadolu Efes Istanbul EFE |
| 5 | October 22, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 82-94 | Valencia Basket VAL |
| 6 | October 29, 2020 CET: 18:00 | LDLC ASVEL Villeurbanne ASV | 74-83 | Zalgiris Kaunas ZAL |
| 7 | November 06, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 90-93 | Real Madrid RMB |
| 8 | November 12, 2020 CET: 20:05 | Maccabi Playtika Tel Aviv MTA | 85-57 | Zalgiris Kaunas ZAL |
| 9 | November 17, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 78-87 | CSKA Moscow CSK |
| 10 | November 20, 2020 CET: 20:45 | AX Armani Exchange Milan AXM | 98-92 | Zalgiris Kaunas ZAL |
| 11 | November 26, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 75-83 | Zenit St Petersburg ZEN |
| 12 | December 04, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 62-73 | FC Barcelona BAR |
| 13 | December 11, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 69-81 | Zalgiris Kaunas ZAL |
| 14 | December 15, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 92-73 | TD Systems Baskonia Vitoria-Gasteiz TDB |
| 15 | December 17, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 99-62 | Fenerbahce Beko Istanbul FBI |
| 16 | December 23, 2020 CET: 18:00 | Zalgiris Kaunas ZAL | 74-73 | FC Bayern Munich BAY |
| 17 | December 29, 2020 CET: 20:00 | ALBA Berlin ALB | 71-74 | Zalgiris Kaunas ZAL |
| 18 | January 08, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 102-75 | Khimki Moscow Region KHI |
| 19 | January 13, 2021 CET: 18:00 | CSKA Moscow CSK | 83-73 | Zalgiris Kaunas ZAL |
| 20 | January 15, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 77-65 | Zalgiris Kaunas ZAL |
| 21 | January 22, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 81-79 | Olympiacos Piraeus OLY |
| 22 | January 27, 2021 CET: 21:00 | Valencia Basket VAL | 78-79 | Zalgiris Kaunas ZAL |
| 23 | January 29, 2021 CET: 21:00 | TD Systems Baskonia Vitoria-Gasteiz TDB | 81-68 | Zalgiris Kaunas ZAL |
| 24 | February 04, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 0-0 | Crvena Zvezda mts Belgrade CZV |
| 25 | February 18, 2021 CET: 21:00 | FC Barcelona BAR | 86-62 | Zalgiris Kaunas ZAL |
| 26 | February 25, 2021 CET: 21:00 | Real Madrid RMB | 70-58 | Zalgiris Kaunas ZAL |
| 27 | March 03, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 85-75 | LDLC ASVEL Villeurbanne ASV |
| 28 | March 05, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 64-69 | AX Armani Exchange Milan AXM |
| 29 | March 12, 2021 CET: 18:30 | Anadolu Efes Istanbul EFE | 0-0 | Zalgiris Kaunas ZAL |
| 30 | March 18, 2021 CET: 18:45 | Fenerbahce Beko Istanbul FBI | 0-0 | Zalgiris Kaunas ZAL |
| 31 | March 26, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 0-0 | Maccabi Playtika Tel Aviv MTA |
| 32 | March 31, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 0-0 | ALBA Berlin ALB |
| 33 | April 02, 2021 CET: 20:30 | FC Bayern Munich BAY | 0-0 | Zalgiris Kaunas ZAL |
| 34 | April 08, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 0-0 | Panathinaikos OPAP Athens PAO |
