| 1 | October 02, 2020 CET: 19:00 | Khimki Moscow Region KHI | 76-78 | Panathinaikos OPAP Athens PAO |
| 2 | October 09, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 71-78 | Olympiacos Piraeus OLY |
| 3 | December 01, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 97-73 | Panathinaikos OPAP Athens PAO |
| 4 | October 15, 2020 CET: 21:00 | FC Barcelona BAR | 97-89 | Panathinaikos OPAP Athens PAO |
| 5 | October 22, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 82-68 | Fenerbahce Beko Istanbul FBI |
| 6 | February 17, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 0-0 | Panathinaikos OPAP Athens PAO |
| 7 | November 06, 2020 CET: 20:30 | Panathinaikos OPAP Athens PAO | 83-89 | CSKA Moscow CSK |
| 8 | November 13, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 77-80 | Anadolu Efes Istanbul EFE |
| 9 | November 17, 2020 CET: 21:00 | Valencia Basket VAL | 95-83 | Panathinaikos OPAP Athens PAO |
| 10 | November 19, 2020 CET: 20:30 | TD Systems Baskonia Vitoria-Gasteiz TDB | 93-72 | Panathinaikos OPAP Athens PAO |
| 11 | November 27, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 83-76 | FC Bayern Munich BAY |
| 12 | December 03, 2020 CET: 20:45 | AX Armani Exchange Milan AXM | 77-80 | Panathinaikos OPAP Athens PAO |
| 13 | December 11, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 69-81 | Zalgiris Kaunas ZAL |
| 14 | December 15, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 93-97 | Real Madrid RMB |
| 15 | December 17, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 92-69 | ALBA Berlin ALB |
| 16 | December 22, 2020 CET: 20:05 | Maccabi Playtika Tel Aviv MTA | 89-81 | Panathinaikos OPAP Athens PAO |
| 17 | December 30, 2020 CET: 19:00 | Crvena Zvezda mts Belgrade CZV | 74-71 | Panathinaikos OPAP Athens PAO |
| 18 | January 07, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 77-89 | Zenit St Petersburg ZEN |
| 19 | January 13, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 88-71 | LDLC ASVEL Villeurbanne ASV |
| 20 | January 15, 2021 CET: 18:45 | Fenerbahce Beko Istanbul FBI | 100-74 | Panathinaikos OPAP Athens PAO |
| 21 | January 21, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 94-78 | Khimki Moscow Region KHI |
| 22 | January 27, 2021 CET: 21:00 | Real Madrid RMB | 76-66 | Panathinaikos OPAP Athens PAO |
| 23 | January 29, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 91-72 | Valencia Basket VAL |
| 24 | February 05, 2021 CET: 20:00 | Olympiacos Piraeus OLY | 77-88 | Panathinaikos OPAP Athens PAO |
| 25 | February 19, 2021 CET: 18:00 | CSKA Moscow CSK | 0-0 | Panathinaikos OPAP Athens PAO |
| 26 | February 26, 2021 CET: 20:00 | ALBA Berlin ALB | 74-65 | Panathinaikos OPAP Athens PAO |
| 27 | March 02, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 77-85 | FC Barcelona BAR |
| 28 | March 04, 2021 CET: 20:30 | FC Bayern Munich BAY | 76-71 | Panathinaikos OPAP Athens PAO |
| 29 | March 11, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 0-0 | Maccabi Playtika Tel Aviv MTA |
| 30 | March 19, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 0-0 | Crvena Zvezda mts Belgrade CZV |
| 31 | March 25, 2021 CET: 18:30 | Anadolu Efes Istanbul EFE | 0-0 | Panathinaikos OPAP Athens PAO |
| 32 | March 30, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 0-0 | TD Systems Baskonia Vitoria-Gasteiz TDB |
| 33 | April 01, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 0-0 | AX Armani Exchange Milan AXM |
| 34 | April 08, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 0-0 | Panathinaikos OPAP Athens PAO |
