| 1 | October 02, 2020 CET: 21:00 | TD Systems Baskonia Vitoria-Gasteiz TDB | 76-63 | Real Madrid RMB |
| 2 | October 08, 2020 CET: 21:00 | Real Madrid RMB | 77-93 | Valencia Basket VAL |
| 3 | October 14, 2020 CET: 21:00 | Real Madrid RMB | 94-85 | Khimki Moscow Region KHI |
| 4 | October 16, 2020 CET: 20:45 | AX Armani Exchange Milan AXM | 78-70 | Real Madrid RMB |
| 5 | October 23, 2020 CET: 21:00 | FC Barcelona BAR | 79-72 | Real Madrid RMB |
| 6 | October 29, 2020 CET: 21:00 | Real Madrid RMB | 100-82 | FC Bayern Munich BAY |
| 7 | November 06, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 90-93 | Real Madrid RMB |
| 8 | November 13, 2020 CET: 19:00 | Crvena Zvezda mts Belgrade CZV | 67-73 | Real Madrid RMB |
| 9 | November 18, 2020 CET: 18:30 | Real Madrid RMB | 79-63 | Maccabi Playtika Tel Aviv MTA |
| 10 | November 20, 2020 CET: 21:00 | Real Madrid RMB | 94-74 | Fenerbahce Beko Istanbul FBI |
| 11 | November 26, 2020 CET: 18:00 | CSKA Moscow CSK | 74-73 | Real Madrid RMB |
| 12 | December 04, 2020 CET: 21:00 | Real Madrid RMB | 91-84 | LDLC ASVEL Villeurbanne ASV |
| 13 | December 10, 2020 CET: 21:00 | Real Madrid RMB | 79-72 | Zenit St Petersburg ZEN |
| 14 | December 15, 2020 CET: 20:00 | Panathinaikos OPAP Athens PAO | 93-97 | Real Madrid RMB |
| 15 | December 18, 2020 CET: 20:00 | Olympiacos Piraeus OLY | 82-86 | Real Madrid RMB |
| 16 | December 22, 2020 CET: 21:00 | Real Madrid RMB | 91-62 | ALBA Berlin ALB |
| 17 | December 29, 2020 CET: 18:30 | Anadolu Efes Istanbul EFE | 65-73 | Real Madrid RMB |
| 18 | January 08, 2021 CET: 21:00 | Real Madrid RMB | 76-80 | AX Armani Exchange Milan AXM |
| 19 | January 13, 2021 CET: 21:00 | Real Madrid RMB | 77-79 | Crvena Zvezda mts Belgrade CZV |
| 20 | January 15, 2021 CET: 20:30 | FC Bayern Munich BAY | 76-81 | Real Madrid RMB |
| 21 | January 21, 2021 CET: 20:05 | Maccabi Playtika Tel Aviv MTA | 86-84 | Real Madrid RMB |
| 22 | January 27, 2021 CET: 21:00 | Real Madrid RMB | 76-66 | Panathinaikos OPAP Athens PAO |
| 23 | January 29, 2021 CET: 20:00 | ALBA Berlin ALB | 63-72 | Real Madrid RMB |
| 24 | February 05, 2021 CET: 21:00 | Real Madrid RMB | 64-84 | TD Systems Baskonia Vitoria-Gasteiz TDB |
| 25 | February 19, 2021 CET: 21:00 | Valencia Basket VAL | 89-78 | Real Madrid RMB |
| 26 | February 25, 2021 CET: 21:00 | Real Madrid RMB | 70-58 | Zalgiris Kaunas ZAL |
| 27 | March 02, 2021 CET: 18:00 | Khimki Moscow Region KHI | 78-77 | Real Madrid RMB |
| 28 | March 04, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 71-75 | Real Madrid RMB |
| 29 | March 11, 2021 CET: 21:00 | Real Madrid RMB | 0-0 | FC Barcelona BAR |
| 30 | March 18, 2021 CET: 21:00 | Real Madrid RMB | 0-0 | CSKA Moscow CSK |
| 31 | March 25, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 0-0 | Real Madrid RMB |
| 32 | March 30, 2021 CET: 21:00 | Real Madrid RMB | 0-0 | Anadolu Efes Istanbul EFE |
| 33 | April 02, 2021 CET: 21:00 | Real Madrid RMB | 0-0 | Olympiacos Piraeus OLY |
| 34 | April 08, 2021 CET: 19:45 | Fenerbahce Beko Istanbul FBI | 0-0 | Real Madrid RMB |
