| 1 | October 01, 2020 CET: 19:30 | Anadolu Efes Istanbul EFE | 69-73 | Zenit St Petersburg ZEN |
| 2 | October 09, 2020 CET: 19:00 | Zenit St Petersburg ZEN | 74-70 | FC Barcelona BAR |
| 3 | November 23, 2020 CET: 19:30 | TD Systems Baskonia Vitoria-Gasteiz TDB | 70-77 | Zenit St Petersburg ZEN |
| 4 | December 08, 2020 CET: 21:00 | Valencia Basket VAL | 72-85 | Zenit St Petersburg ZEN |
| 5 | February 22, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 0-0 | AX Armani Exchange Milan AXM |
| 6 | February 17, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 0-0 | Panathinaikos OPAP Athens PAO |
| 7 | November 05, 2020 CET: 18:00 | Zenit St Petersburg ZEN | 66-75 | Olympiacos Piraeus OLY |
| 8 | November 13, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 53-66 | Zenit St Petersburg ZEN |
| 9 | November 17, 2020 CET: 18:00 | Zenit St Petersburg ZEN | 83-88 | Khimki Moscow Region KHI |
| 10 | November 20, 2020 CET: 20:00 | ALBA Berlin ALB | 66-73 | Zenit St Petersburg ZEN |
| 11 | November 26, 2020 CET: 19:00 | Zalgiris Kaunas ZAL | 75-83 | Zenit St Petersburg ZEN |
| 12 | December 03, 2020 CET: 18:00 | Zenit St Petersburg ZEN | 65-73 | Fenerbahce Beko Istanbul FBI |
| 13 | December 10, 2020 CET: 21:00 | Real Madrid RMB | 79-72 | Zenit St Petersburg ZEN |
| 14 | December 16, 2020 CET: 17:00 | Zenit St Petersburg ZEN | 79-75 | FC Bayern Munich BAY |
| 15 | December 18, 2020 CET: 18:00 | CSKA Moscow CSK | 83-65 | Zenit St Petersburg ZEN |
| 16 | December 22, 2020 CET: 18:00 | Zenit St Petersburg ZEN | 98-69 | Crvena Zvezda mts Belgrade CZV |
| 17 | December 29, 2020 CET: 20:05 | Maccabi Playtika Tel Aviv MTA | 72-78 | Zenit St Petersburg ZEN |
| 18 | January 07, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 77-89 | Zenit St Petersburg ZEN |
| 19 | January 13, 2021 CET: 20:30 | FC Bayern Munich BAY | 82-80 | Zenit St Petersburg ZEN |
| 20 | January 15, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 77-65 | Zalgiris Kaunas ZAL |
| 21 | January 21, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 85-78 | Anadolu Efes Istanbul EFE |
| 22 | January 26, 2021 CET: 21:00 | FC Barcelona BAR | 85-81 | Zenit St Petersburg ZEN |
| 23 | January 28, 2021 CET: 20:45 | AX Armani Exchange Milan AXM | 82-76 | Zenit St Petersburg ZEN |
| 24 | February 05, 2021 CET: 18:45 | Fenerbahce Beko Istanbul FBI | 92-84 | Zenit St Petersburg ZEN |
| 25 | February 19, 2021 CET: 20:45 | Crvena Zvezda mts Belgrade CZV | 75-76 | Zenit St Petersburg ZEN |
| 26 | February 25, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 62-91 | Valencia Basket VAL |
| 27 | March 02, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 87-71 | ALBA Berlin ALB |
| 28 | March 04, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 71-75 | Real Madrid RMB |
| 29 | March 12, 2021 CET: 20:00 | Olympiacos Piraeus OLY | 0-0 | Zenit St Petersburg ZEN |
| 30 | March 18, 2021 CET: 18:00 | Zenit St Petersburg ZEN | 0-0 | TD Systems Baskonia Vitoria-Gasteiz TDB |
| 31 | March 26, 2021 CET: 18:00 | Khimki Moscow Region KHI | 0-0 | Zenit St Petersburg ZEN |
| 32 | March 30, 2021 CET: 19:00 | Zenit St Petersburg ZEN | 0-0 | CSKA Moscow CSK |
| 33 | April 02, 2021 CET: 19:00 | Zenit St Petersburg ZEN | 0-0 | LDLC ASVEL Villeurbanne ASV |
| 34 | April 09, 2021 CET: 19:00 | Zenit St Petersburg ZEN | 0-0 | Maccabi Playtika Tel Aviv MTA |
