| 1 | October 01, 2020 CET: 21:00 | Valencia Basket VAL | 65-63 | LDLC ASVEL Villeurbanne ASV |
| 2 | October 09, 2020 CET: 20:45 | AX Armani Exchange Milan AXM | 87-73 | LDLC ASVEL Villeurbanne ASV |
| 3 | December 01, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 97-73 | Panathinaikos OPAP Athens PAO |
| 4 | November 11, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 68-89 | Crvena Zvezda mts Belgrade CZV |
| 6 | October 29, 2020 CET: 18:00 | LDLC ASVEL Villeurbanne ASV | 74-83 | Zalgiris Kaunas ZAL |
| 7 | November 05, 2020 CET: 20:30 | TD Systems Baskonia Vitoria-Gasteiz TDB | 86-88 | LDLC ASVEL Villeurbanne ASV |
| 8 | November 13, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 53-66 | Zenit St Petersburg ZEN |
| 9 | November 18, 2020 CET: 20:00 | ALBA Berlin ALB | 76-75 | LDLC ASVEL Villeurbanne ASV |
| 10 | January 19, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 0-0 | Olympiacos Piraeus OLY |
| 11 | November 27, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 80-68 | FC Barcelona BAR |
| 12 | December 04, 2020 CET: 21:00 | Real Madrid RMB | 91-84 | LDLC ASVEL Villeurbanne ASV |
| 13 | December 11, 2020 CET: 20:30 | FC Bayern Munich BAY | 76-62 | LDLC ASVEL Villeurbanne ASV |
| 14 | December 16, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 84-81 | Maccabi Playtika Tel Aviv MTA |
| 15 | December 18, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 90-84 | Khimki Moscow Region KHI |
| 16 | December 22, 2020 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 78-87 | CSKA Moscow CSK |
| 17 | December 30, 2020 CET: 18:45 | Fenerbahce Beko Istanbul FBI | 81-59 | LDLC ASVEL Villeurbanne ASV |
| 18 | January 08, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 80-102 | Anadolu Efes Istanbul EFE |
| 19 | January 13, 2021 CET: 20:00 | Panathinaikos OPAP Athens PAO | 88-71 | LDLC ASVEL Villeurbanne ASV |
| 20 | January 15, 2021 CET: 20:30 | Olympiacos Piraeus OLY | 63-69 | LDLC ASVEL Villeurbanne ASV |
| 21 | January 21, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 90-77 | Valencia Basket VAL |
| 22 | January 27, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 83-77 | TD Systems Baskonia Vitoria-Gasteiz TDB |
| 23 | January 29, 2021 CET: 20:45 | Crvena Zvezda mts Belgrade CZV | 78-81 | LDLC ASVEL Villeurbanne ASV |
| 24 | February 05, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 78-69 | AX Armani Exchange Milan AXM |
| 25 | February 19, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 87-79 | FC Bayern Munich BAY |
| 26 | February 26, 2021 CET: 21:00 | FC Barcelona BAR | 69-76 | LDLC ASVEL Villeurbanne ASV |
| 27 | March 03, 2021 CET: 19:00 | Zalgiris Kaunas ZAL | 85-75 | LDLC ASVEL Villeurbanne ASV |
| 28 | March 05, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 86-90 | Fenerbahce Beko Istanbul FBI |
| 29 | March 11, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 0-0 | ALBA Berlin ALB |
| 30 | March 18, 2021 CET: 20:05 | Maccabi Playtika Tel Aviv MTA | 0-0 | LDLC ASVEL Villeurbanne ASV |
| 31 | March 25, 2021 CET: 20:45 | LDLC ASVEL Villeurbanne ASV | 0-0 | Real Madrid RMB |
| 32 | March 31, 2021 CET: 19:00 | Khimki Moscow Region KHI | 0-0 | LDLC ASVEL Villeurbanne ASV |
| 33 | April 02, 2021 CET: 19:00 | Zenit St Petersburg ZEN | 0-0 | LDLC ASVEL Villeurbanne ASV |
| 34 | April 08, 2021 CET: 19:00 | CSKA Moscow CSK | 0-0 | LDLC ASVEL Villeurbanne ASV |
